The McManus lab uses systematic and synthetic approaches to study fundamental processes relating to the regulation of gene function. We operate in a diversity of research areas- including RNA biology and developing cutting-edge research tools to answer fundamental biological questions. We take high-throughput approaches, analyzing hundreds of thousands to millions of experiments at once, using unique and complex libraries coupled to deep sequencing.  Our systems span from cell culture to in vivo models, focusing on a broad array of disease relevant tissues.  From cancer to diabetes, we develop novel technologies to help us better understand how genes are regulated and how they function in cells.  We aim to uncover the dark matter of the genome, to help unravel the beautiful genomic complexity of pathways and how genes interact in development and disease. We develop new technologies to address unmet challenges and advance science in leaps and bounds through collaboration. 

The McManus Lab is about collaboration and sharing of ideas. Together we are dedicated to helping each other achieve great success through sharing and collaboration. We encourage presentation of unpublished results and sharing reagents. We are dedicated to maximizing diversity and promoting equality. As a member of the University of California, San Francisco, we are committed to respecting and supporting the individuality of each current and prospective community member. We affirm our PRIDE values (Professionalism, Respect, Integrity, Diversity and Excellence) and Principles of Community, which are the cornerstone for everything we do and unite our faculty, students, researchers, caregivers, and staff in building a culture of collaboration that inspires us to be our best today, and in the future. We commit to identifying and dismantling prejudicial systems by enacting practices supporting our values of diversity, equity, and inclusion.