Ruzbeh Mosadeghi, PhD MD

After completing my MD degree at the Keck School of Medicine of the University of Southern California and my Internal Medicine residency at Columbia, I joined the University of California, San Francisco School of Medicine as a research track gastroenterology fellow.

My scientific research background is in ubiquitin biochemistry and its role in protein homeostasis. In 2015 I completed my PhD thesis with Ray Deshaies at Caltech where I focused on studying the activation and deactivation of a subclass of ubiquitin ligases. Specifically, I studied the kinetics of deactivation of Cullin-RING ligases (CRLs) by the Cop9 Signalosome (CSN). I used pre-steady state kinetics to elucidate their mechanism and proteomics to understand the cellular repercussions of introducing mutations. These pathways are relevant to a broad range of regulatory pathways in cells and associated with aging and human disease.

My immediate research interests are in inflammatory bowel diseases, specifically the molecular mechanisms of pathogenesis. I hope that my research will not only shed fundamental light on how the disease occurs and progresses, but will help treat patients. Broadly, I am interested in the role of T-cells and antigen presenting cells in inflammatory bowel disease, and the intrinsic intestinal cell cues that trigger immune infiltration of the intestine.

I am currently developing novel high-throughput screening technologies to study inflammatory bowel disease in intestinal organoid models. My work may uncover molecular mechanisms of inflammatory bowel disease and reveal novel therapeutic targets for intervention of this disease.

Outside of lab, I enjoy hanging out with my son, cooking, skiing, hiking and SCUBA diving every chance I get!