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2019
High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions.. Vol 27.; 2019. (Cell Rep; vol 27; no 2).
The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research.. Vol 177.; 2019. (Cell; vol 177; no 2).
Genomic Resolution of DLX-Orchestrated Transcriptional Circuits Driving Development of Forebrain GABAergic Neurons.. Vol 28.; 2019. (Cell Rep; vol 28; no 8).
Tracing cellular heterogeneity in pooled genetic screens via multi-level barcoding.. Vol 20.; 2019. (BMC Genomics; vol 20; no 1).
miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival.. Vol 28.; 2019. (Cell Rep; vol 28; no 8).
BCAA catabolism in brown fat controls energy homeostasis through SLC25A44.. Vol 572.; 2019. (Nature; vol 572; no 7771).
2018
Dual Strategies for Argonaute2-Mediated Biogenesis of Erythroid miRNAs Underlie Conserved Requirements for Slicing in Mammals.. Vol 69.; 2018. (Mol Cell; vol 69; no 2).
Dual gene activation and knockout screen reveals directional dependencies in genetic networks..; 2018. (Nat Biotechnol).
Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation..; 2018. (Proc Natl Acad Sci USA).
Far away from the lamppost.. Vol 16.; 2018. (PLoS Biol; vol 16; no 12).
The Transcriptionally Permissive Chromatin State of Embryonic Stem Cells Is Acutely Tuned to Translational Output.. Vol 22.; 2018. (Cell Stem Cell; vol 22; no 3).
Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2.. Vol 25.; 2018. (Cell Rep; vol 25; no 6).
Unexplored therapeutic opportunities in the human genome..; 2018. (Nat Rev Drug Discov).
2017
miR-205 is a critical regulator of lacrimal gland development..; 2017. (Dev Biol).
A systematic comparison reveals substantial differences in chromosomal versus episomal encoding of enhancer activity.. Vol 27.; 2017. (Genome Res; vol 27; no 1).
Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition..; 2017. (Nature).
MicroRNAs in ectodermal appendages.. Vol 43.; 2017. (Curr Opin Genet Dev; vol 43).
Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland.. Vol 144.; 2017. (Development; vol 144; no 13).
2016
PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression.. Vol 22.; 2016. (Nat Med; vol 22; no 11).
2015
Epigenetic and transcriptional determinants of the human breast.. Vol 6.; 2015. (Nat Commun; vol 6).
Biogenesis, delivery, and function of extracellular RNA.. Vol 4.; 2015. (J Extracell Vesicles; vol 4).
Identification of MiR-205 As a MicroRNA That Is Highly Expressed in Medullary Thymic Epithelial Cells.. Vol 10.; 2015. (PLoS ONE; vol 10; no 8).
Choosing the Right Tool for the Job: RNAi, TALEN, or CRISPR.. Vol 58.; 2015. (Mol Cell; vol 58; no 4).
Integrative analysis of 111 reference human epigenomes.. Vol 518.; 2015. (Nature; vol 518; no 7539).
2014
Dicer Regulates Differentiation and Viability during Mouse Pancreatic Cancer Initiation.. Vol 9.; 2014. (PLoS ONE; vol 9; no 5).
Systematic Identification of Barriers to Human iPSC Generation.. Vol 158.; 2014. (Cell; vol 158; no 2).
Characterization of the structural modifications accompanying the loss of HBsAg particle immunogenicity.. Vol 32.; 2014. (Vaccine; vol 32; no 9).
Massively parallel functional annotation of 3' untranslated regions..; 2014. (Nat Biotechnol).
Discovering the complexity of the metazoan transcriptome.. Vol 15.; 2014. (Genome Biol; vol 15; no 4).
A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation.. Vol 5.; 2014. (Nat Commun; vol 5).
2013
Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs.. Vol 9.; 2013. (PLoS Genet; vol 9; no 6).
The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation. Development. 2013;140(16):3348-59.
Partially Penetrant Postnatal Lethality of an Epithelial Specific MicroRNA in a Mouse Knockout. PLoS ONE. 2013;8(10):e76634.
T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. J Exp Med. 2013;210(2):417-32.
Next-Generation NAMPT Inhibitors Identified by Sequential High-Throughput Phenotypic Chemical and Functional Genomic Screens. Chem Biol. 2013;20(11):1352-63.
A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. Cell. 2013;152(4):909-22.
Renewable RNAi. Nat Biotechnol. 2013;31(4):319-20.
Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs. PLoS Genet. 2013;9(6):e1003569.
2012
Research resource: RNA-Seq reveals unique features of the pancreatic β-cell transcriptome.. Vol 26.; 2012. (Mol Endocrinol; vol 26; no 10).
The structure of HBsAg particles is not modified upon their adsorption on aluminium hydroxide gel.. Vol 30.; 2012. (Vaccine; vol 30; no 35).
Widespread RNA 3'-end oligouridylation in mammals. RNA. 2012;18(3):394-401.
IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science. 2012;338(6108):818-22.
Precursor microRNA-programmed silencing complex assembly pathways in mammals. Mol Cell. 2012;46(4):507-17.
A resource for the conditional ablation of microRNAs in the mouse. Cell Rep. 2012;1(4):385-91.
Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing. Nucleic Acids Res. 2012;40(18):9255-71.
An siRNA screen in pancreatic beta cells reveals a role for Gpr27 in insulin production. PLoS Genet. 2012;8(1):e1002449.
Research resource: RNA-Seq reveals unique features of the pancreatic β-cell transcriptome. Mol Endocrinol. 2012;26(10):1783-92.
2011
Characterization of the mechanisms of HIV-1 Vpr(52-96) internalization in cells.. Vol 93.; 2011. (Biochimie; vol 93; no 10).
The microRNA-processing enzyme Dicer is dispensable for somite segmentation but essential for limb bud positioning. Dev Biol. 2011;351(2):254-65.
Polymerase II promoter strength determines efficacy of microRNA adapted shRNAs. PLoS ONE. 2011;6(10):e26213.
2010
Characterization of the lipid and protein organization in HBsAg viral particles by steady-state and time-resolved fluorescence spectroscopy.. Vol 92.; 2010. (Biochimie; vol 92; no 8).
Analysis of microRNA knockouts in mice. Hum Mol Genet. 2010;19(R2):R169-75.
Dicer1 and miR-219 Are required for normal oligodendrocyte differentiation and myelination. Neuron. 2010;65(5):597-611.
2009
Genetic analyses reveal a requirement for Dicer1 in the mouse urogenital tract. Mamm Genome. 2009;20(3):140-51.
Chd1 regulates open chromatin and pluripotency of embryonic stem cells. Nature. 2009;460(7257):863-8.
Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis. Gastroenterology. 2009;136(7):2304-2315.e1-4.
Dicer is required for proper liver zonation. J Pathol. 2009;219(3):365-72.
Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice. Dev Biol. 2009;328(2):328-41.
Expanded RNA-binding activities of mammalian Argonaute 2. Nucleic Acids Res. 2009;37(22):7533-45.
Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion. J Biol Chem. 2009;284(27):18515-24.
Dicer ablation in oligodendrocytes provokes neuronal impairment in mice. Ann Neurol. 2009;66(6):843-57.
LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages. FASEB J. 2009;23(9):2898-908.
Sertoli cell Dicer is essential for spermatogenesis in mice. Dev Biol. 2009;326(1):250-9.
Rapid creation and quantitative monitoring of high coverage shRNA libraries. Nat Methods. 2009;6(6):443-5.
2008
Unintentional miRNA ablation is a risk factor in gene knockout studies: a short report. PLoS Genet. 2008;4(2):e34.
Dicer1 is required for differentiation of the mouse male germline. Biol Reprod. 2008;79(4):696-703.
Michael T. McManus: Interrupting biology [interview by Hema Bashyam]. J Exp Med. 2008;205(3):506-7.
Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J Exp Med. 2008;205(9):1983-91.
Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron. 2008;57(1):41-55.
Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration. Proc Natl Acad Sci USA. 2008;105(14):5614-9.
Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. J Am Soc Nephrol. 2008;19(11):2150-8.
Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci. 2008;28(19):4878-87.
Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J Neurosci. 2008;28(17):4322-30.
Behind the scenes of a small RNA gene-silencing pathway. Hum Gene Ther. 2008;19(1):17-26.
2007
Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell. 2007;129(2):303-17.
MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes. 2007;56(12):2938-45.
Lentiviral strategies for RNAi knockdown of neuronal genes. Curr Protoc Neurosci. 2007;Chapter 5:Unit 5.26.
Essential role for Dicer during skeletal muscle development. Dev Biol. 2007;311(2):359-68.
2006
Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci USA. 2006;103(7):2208-13.
RNA interference in embryonic stem cells and the prospects for future therapies. Gene Ther. 2006;13(6):478-86.
Duox2 exhibits potent heme peroxidase activity in human respiratory tract epithelium. FEBS Lett. 2006;580(22):5150-4.
2005
The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci USA. 2005;102(31):10898-903.
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science. 2005;309(5737):1074-8.
Slowing down the Ras lane: miRNAs as tumor suppressors? Sci STKE. 2005;2005(297):pe41.
The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development. Nature. 2005;438(7068):671-4.
MicroRNAs and endocrine biology. J Endocrinol. 2005;187(3):327-32.
2004
Cre-lox-regulated conditional RNA interference from transgenes. Proc Natl Acad Sci USA. 2004;101(28):10380-5.
Small RNAs and immunity. Immunity. 2004;21(6):747-56.
2003
RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription. Proc Natl Acad Sci USA. 2003;100(5):2718-23.
MicroRNAs and cancer. Semin Cancer Biol. 2003;13(4):253-8.
2002
Gene silencing using micro-RNA designed hairpins. RNA. 2002;8(6):842-50.
Gene silencing in mammals by small interfering RNAs. Nat Rev Genet. 2002;3(10):737-47.
CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. Dev Cell. 2002;3(3):339-50.
Small interfering RNA-mediated gene silencing in T lymphocytes. J Immunol. 2002;169(10):5754-60.
2001
Identification of candidate mitochondrial RNA editing ligases from Trypanosoma brucei. RNA. 2001;7(2):167-75.
2000
Trypanosoma brucei guide RNA poly(U) tail formation is stabilized by cognate mRNA. Mol Cell Biol. 2000;20(3):883-91.
Processing of polycistronic guide RNAs is associated with RNA editing complexes in Trypanosoma brucei. EMBO J. 2000;19(20):5525-32.
1998
Biochemical methods for analysis of kinetoplastid RNA editing. Methods. 1998;15(1):15-26.
1997
Insertional and deletional RNA editing in trypanosome mitochondria. Nucleic Acids Symp Ser. 1997;(36):15-8.