The McManus Lab at UCSF develops scalable tools to measure and engineer living systems, focusing on gene regulation, immune recognition, and designed cell-to-cell communication. We combine synthetic biology, functional genomics, and quantitative immunology to tackle a common challenge: many of biology’s most important traits emerge from dynamic, interconnected networks and depend on interactions over time.
Research Projects
Research contributions: past and present
CURRENT CONTRIBUTIONS TO SCIENCE
Pooled CRISPR Imaging
Multiplexed Perturbation
Immune Specificity
Vesicle Barcoding
Cell Interaction
Microbiome Dynamics
PAST CONTRIBUTIONS TO SCIENCE
Genetics and RNA
Regulatory Genome
Cell Fate Control
Genetic Networks
CRISPRi In Vivo
Team Science
Affiliations
We are members of the Department of Microbiology and Immunology, UCSF Helen Diller Family Comprehensive Cancer Center, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF, and ImmunoX.
For a full list of publications, see Google Scholar.
