Dr. McManus completed his postdoctoral training as a Cancer Research Institute fellow at the intersection of RNA-based technologies and its applications to human disease. In the laboratory of Nobel Laureate Phillip A. Sharp in the Center for Cancer Research at the MIT, he studied the role of RNA-interference pathways in mammals, developing tools to probe gene regulation. Since 2004 he has been a principle investigator at UCSF, overseeing a very productive and interactive lab at UCSF, studying the basic biological processes relating to gene regulation and cell biology, using cultured cells and the mouse as a model. In 2010 Dr. McManus was awarded tenure in the Department of Microbiology and Immunology, and thereafter bestowed a Vincent and Stella Coates Endowed Chair for research excellence. He founded the W.M. Keck Center for Noncoding RNAs and a heavily used ViraCore at UCSF. At UCSF he has been granted a number of noteworthy research awards for excellence in technologies and collaboration: the Sandler Integrative Science Award, the New Technologies Award, the PBBR Science Award, Breakthrough Technologies Award, and the WM Keck Award. He was recently awarded a Transformative Award from the NIH Directors Office for his pioneering research on the reconstruction of ancestral cells by enzymatic recording. Indeed his work has a strong technology component, having developed cutting-edge research tools and large-scale resources that relate to small RNAs (microRNA, RNAi, and CRISPR) for the interrogation of gene function and their potential use in the intervention of human disease. His lab has built many mouse and human genome-scale lentiviral libraries, mouse and human genome shRNA and Cas9 libraries, pioneered novel high-throughput cell-based screening technologies, and is highly collaborative. He maintains a very diverse program, with students and postdocs and research technicians working in a variety of research areas.

recent publications

Inoue F, Kircher M, Martin B, Cooper GM, Witten DM, McManus MT, et al. A systematic comparison reveals substantial differences in chromosomal versus episomal encoding of enhancer activity.. Vol 27.; 2017. (Genome Res; vol 27; no 1).
Farmer D', McManus MT. MicroRNAs in ectodermal appendages.. Vol 43.; 2017. (Curr Opin Genet Dev; vol 43).
Pappalardo Z, Chopra DG, Hennings TG, Richards H, Choe J, Yang K, et al. A Whole Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response..; 2017. (Diabetes).
Farmer D', Nathan S, Finley JK, Yu KS, Emmerson E, Byrnes LE, et al. Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland.. Vol 144.; 2017. (Development; vol 144; no 13).
Farmer D', Finley JK, Chen FY, TarifeƱo-Saldivia E, McNamara NA, Knox SM, et al. miR-205 is a critical regulator of lacrimal gland development..; 2017. (Dev Biol).
Gerhard DS, Clemons PA, Shamji AF, Hon C, Wagner BK, Schreiber SL, et al. Transforming Big Data into cancer-relevant insight: An initial, multi-tier approach to assess reproducibility and relevance..; 2016. (Mol Cancer Res).
Horiuchi D, Camarda R, Zhou AY, Yau C, Momcilovic O, Balakrishnan S, et al. PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression.. Vol 22.; 2016. (Nat Med; vol 22; no 11).
Patton JG, Franklin JL, Weaver AM, Vickers K, Zhang B, Coffey RJ, et al. Biogenesis, delivery, and function of extracellular RNA.. Vol 4.; 2015. (J Extracell Vesicles; vol 4).
Khan IS, Park CY, Mavropoulos A, Shariat N, Pollack JL, Barczak AJ, et al. Identification of MiR-205 As a MicroRNA That Is Highly Expressed in Medullary Thymic Epithelial Cells.. Vol 10.; 2015. (PLoS ONE; vol 10; no 8).