edeklerk



My scientific background has been shaped between Italy and The Netherlands, reflecting my dual nationality.

I obtained my B.Sc.(majored in Molecular Biology, 2006) and M.Sc.(Cellular and Molecular Biology, 2009) at the University of Catania (located in sunny Sicily).

My interest in Genomics led me in 2009 to The Netherlands, where I briefly worked as research analyst at the Leiden Genome Technology Center (focusing on NGS), before starting my doctoral training in the Human Genetics department at Leiden University Medical Center in 2010.

In 2015 I obtained my Ph.D. based on my research on post-transcriptional control of gene expression, conducted in the Laboratory of prof. Johan den Dunnen, under the supervision of assoc. prof. Peter-Bram ’t Hoen. In the Den Dunnen lab I investigated alternative regulatory mechanisms shaping gene expression, mainly alternative polyadenylation, based on a diverse set of high-throughput RNA sequencing technologies.

I love travelling (co-first hobby next to Science), snorkeling (beach&sun!), skiing (snow&sun!), biking (Dutch genes!) accompanied by good Food (Italian genes!). I go crazy for felines (big&small) and Nature!


recent publications

Wu H, Thijssen PE, de Klerk E, Vonk KK, Wang J, Hamer Bd, et al. Converging disease genes in ICF syndrome: ZBTB24 controls expression of CDCA7 in mammals..; 2016. (Hum Mol Genet).
de Klerk E, Fokkema IF, Thiadens KA, Goeman JJ, Palmblad M, Dunnen JT, et al. Assessing the translational landscape of myogenic differentiation by ribosome profiling.. Vol 43.; 2015. (Nucleic Acids Res; vol 43; no 9).
de Klerk E, Dunnen JT, Hoen PA. RNA sequencing: from tag-based profiling to resolving complete transcript structure.. Vol 71.; 2014. (Cell Mol Life Sci; vol 71; no 18).
Zhernakova DV, de Klerk E, Westra H-, Mastrokolias A, Amini S, Ariyurek Y, et al. DeepSAGE reveals genetic variants associated with alternative polyadenylation and expression of coding and non-coding transcripts.. Vol 9.; 2013. (PLoS Genet; vol 9; no 6).
de Klerk E, Venema A, S Anvar Y, Goeman JJ, Hu O, Trollet C, et al. Poly(A) binding protein nuclear 1 levels affect alternative polyadenylation.. Vol 40.; 2012. (Nucleic Acids Res; vol 40; no 18).