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publications
Dicer is required for proper liver zonation
Sekine S, Ogawa R, McManus MT, Kanai Y, Hebrok M.
J. Pathol
July 27, 2009
Chd1 regulates open chromatin and pluripotency of embryonic stem cells
Alexandre Gaspar-Maia1,2,3, Adi Alajem4, Fanny Polesso1,2, Rupa Sridharan5, Mike J. Mason5, Amy Heidersbach2, João Ramalho-Santos6, Michael T. McManus2, Kathrin Plath5, Eran Meshorer4 & Miguel Ramalho-Santos1,2
Nature
July 8, 2009
Rapid creation and quantitative monitoring of high coverage shRNA libraries.
Bassik MC[1], Lebbink RJ[1], Churchman LS, Ingolia NT, Patena W, Leproust EM, Schuldiner M, Weissman JS, McManus MT.
Nat Methods
May 17, 2009
LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages.
Ruggiero, T., Trabucchi, M., De Santa, F., Zupo, S., Harfe, B. D., McManus, M. T., Rosenfeld, M. G., Briata, P., Gherzi, R.
FASEB J.
May 7, 2009
Up-regulation of miR-21 by HER2/neu Signaling Promotes Cell Invasion.
Huang TH, Wu F, Loeb GB, Hsu R, Heidersbach A, Brincat A, Horiuchi D, Lebbink RJ, Mo YY, Goga A, McManus MT.
J Biol Chem.
May 6, 2009
Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus
Davis TH, Cuellar TL, Koch SM, Barker AJ, Harfe BD, McManus MT, Ullian EM.
J Neurosci.
April 23, 2009
Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice
Soukup GA, Fritzsch B, Pierce ML, Weston MD, Jahan I, McManus MT, Harfe BD.
Developmental Biology
April 15, 2009
Genetic analyses reveal a requirement for Dicer1 in the mouse urogenital tract
Pastorelli L, Wells S, Fray M, Smith A, Hough T, Harfe BD, McManus MT, Smith L, Woolf AS, Cheeseman M, Greenfield A
Mammalian Genome
March 1, 2009
Sertoli cell Dicer is essential for spermatogenesis in mice
Papaioannou MD, Pitetti JL, Ro S, Park C, Aubry F, Schaad O, Vejnar CE, Kühne F, Descombes P, Zdobnov EM, McManus MT, Guillou F, Harfe BD, Yan W, Jégou B, Nef S.
Dev Biol.
February 1, 2009
Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease
Harvey SJ, Jarad G, Cunningham J, Goldberg S, Schermer B, Harfe BD, McManus MT, Benzing T, Miner JH.
J Am Soc Nephrol.
November 1, 2008
Mouse let-7 miRNA populations exhibit RNA editing that is constrained in the 5'-seed/ cleavage/anchor regions and stabilize predicted mmu-let-7a:mRNA duplexes
Reid JG, Nagaraja AK, Lynn FC, Drabek RB, Muzny DM, Shaw CA, Weiss MK, Naghavi AO, Khan M, Zhu H, Tennakoon J, Gunaratne GH, Corry DB, Miller J, McManus MT, German MS, Gibbs RA, Matzuk MM, Gunaratne PH.
Genome Res.
October 1, 2008
Dicer1 is required for differentiation of the mouse male germline
Maatouk DM, Loveland KL, McManus MT, Moore K, Harfe BD.
Biol Reprod.
October 1, 2008
Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity.
Zhou X, Jeker LT, Fife BT, Zhu S, Anderson MS, McManus MT, Bluestone JA.
J Exp Med.
September 1, 2008
Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina
Damiani D, Alexander JJ, O'Rourke JR, McManus M, Jadhav AP, Cepko CL, Hauswirth WW, Harfe BD, Strettoi E.
J Neurosci.
May 7, 2008
Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration
Cuellar TL, Davis TH, Nelson PT, Loeb GB, Harfe BD, Ullian E, McManus MT.
Proc Natl Acad Sci U S A.
April 8, 2008
Unintentional miRNA ablation is a risk factor in gene knockout studies: a short report
Osokine I, Hsu R, Loeb GB, McManus MT.
PLoS Genet.
February 1, 2008
Members of the miRNA-200 family regulate olfactory neurogenesis
Choi PS, Zakhary L, Choi WY, Caron S, Alvarez-Saavedra E, Miska EA, McManus M, Harfe B, Giraldez AJ, Horvitz HR, Schier AF, Dulac C.
Neuron.
January 10, 2008
Behind the scenes of a small RNA gene-silencing pathway
Ku G, McManus MT.
Hum Gene Ther.
January 1, 2008
MicroRNA expression is required for pancreatic islet cell genesis in the mouse
Lynn FC, Skewes-Cox P, Kosaka Y, McManus MT, Harfe BD, German MS.
Diabetes.
December 1, 2007
Essential role for Dicer during skeletal muscle development
O'Rourke JR, Georges SA, Seay HR, Tapscott SJ, McManus MT, Goldhamer DJ, Swanson MS, Harfe BD.
Dev Biol.
November 15, 2007
Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells
Nawroth R, van Zante A, Cervantes S, McManus M, Hebrok M, Rosen SD.
PLoS ONE.
April 25, 2007
Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2
Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, Tsuchihashi T, McManus MT, Schwartz RJ, Srivastava D.
Cell.
April 20, 2007
Lentiviral Strategies for RNAi Knockdown of Neuronal Genes
Jill R. Crittenden1, Amy Heidersbach2, Michael T. McManus2
Current Protocols in Neuroscience
April 15, 2007
Duox2 exhibits potent heme peroxidase activity in human respiratory tract epithelium
Harper RW, Xu C, McManus M, Heidersbach A, Eiserich JP.
FEBS Lett.
October 2, 2006
RNA interference in embryonic stem cells and the prospects for future therapies
Heidersbach A, Gaspar-Maia A, McManus MT, Ramalho-Santos M.
Gene Ther.
March 1, 2006
Dicer function is essential for lung epithelium morphogenesis
Harris KS, Zhang Z, McManus MT, Harfe BD, Sun X.
Proc Natl Acad Sci U S A.
February 14, 2006
The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development
Hornstein E, Mansfield JH, Yekta S, Hu JK, Harfe BD, McManus MT, Baskerville S, Bartel DP, Tabin CJ.
Nature.
December 1, 2005
MicroRNAs and endocrine biology
Cuellar TL, McManus MT.
J Endocrinol.
December 1, 2005
Slowing down the Ras lane: miRNAs as tumor suppressors?
Morris JP 4th, McManus MT.
Sci STKE.
August 16, 2005
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation
Hong JH, Hwang ES, McManus MT, Amsterdam A, Tian Y, Kalmukova R, Mueller E, Benjamin T, Spiegelman BM, Sharp PA, Hopkins N, Yaffe MB.
Science.
August 12, 2005
The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb
Harfe BD, McManus MT, Mansfield JH, Hornstein E, Tabin CJ.
Proc Natl Acad Sci U S A.
August 2, 2005
Small RNAs and immunity
McManus MT.
Immunity.
December 1, 2004
MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression
Mansfield JH, Harfe BD, Nissen R, Obenauer J, Srineel J, Chaudhuri A, Farzan-Kashani R, Zuker M, Pasquinelli AE, Ruvkun G, Sharp PA, Tabin CJ, McManus MT.
Nat Genet.
October 1, 2004
Cre-lox-regulated conditional RNA interference from transgenes
Ventura A, Meissner A, Dillon CP, McManus M, Sharp PA, Van Parijs L, Jaenisch R, Jacks T.
Proc Natl Acad Sci U S A.
July 13, 2004
MicroRNAs and cancer
McManus MT.
Semin Cancer Biol.
August 1, 2003
RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription
Ge Q, McManus MT, Nguyen T, Shen CH, Sharp PA, Eisen HN, Chen J.
Proc Natl Acad Sci U S A.
March 4, 2003
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
Rubinson DA, Dillon CP, Kwiatkowski AV, Sievers C, Yang L, Kopinja J, Rooney DL, Zhang M, Ihrig MM, McManus MT, Gertler FB, Scott ML, Van Parijs L.
Nat Genet.
March 1, 2003
Small interfering RNA-mediated gene silencing in T lymphocytes
McManus MT, Haines BB, Dillon CP, Whitehurst CE, van Parijs L, Chen J, Sharp PA.
J Immunol.
November 15, 2002
Gene silencing in mammals by small interfering RNAs
McManus MT, Sharp PA.
Nat Rev Genet.
October 1, 2002
CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells
Chen Z, Indjeian VB, McManus M, Wang L, Dynlacht BD.
Dev Cell.
September 1, 2002
Gene silencing using micro-RNA designed hairpins
McManus MT, Petersen CP, Haines BB, Chen J, Sharp PA.
RNA
June 1, 2002
Identification of candidate mitochondrial RNA editing ligases from Trypanosoma brucei
McManus MT, Shimamura M, Grams J, Hajduk SL.
RNA.
February 1, 2001
Processing of polycistronic guide RNAs is associated with RNA editing complexes in Trypanosoma brucei
Grams J, McManus MT, Hajduk SL.
EMBO J.
October 16, 2000
Trypanosoma brucei guide RNA poly(U) tail formation is stabilized by cognate mRNA
McManus MT, Adler BK, Pollard VW, Hajduk SL.
Mol Cell Biol.
February 1, 2000
Insertional and deletional RNA editing in trypanosome mitochondria
Hajduk SL, Adler B, Madison-Antenucci S, McManus M, Sabatini R.
Nucleic Acids Symp Ser.
January 1, 1997
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