publications
Renewable RNAi
- Nat Biotechnol. | April 5, 2013
A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility
- Cell | February 7, 2013
T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire
- J Exp Med | February 4, 2013
IRE1α Cleaves Select microRNAs during ER Stress to Derepress Translation of Proapoptotic Caspase-2
- Science | October 4, 2012
RNA-Seq Reveals Unique Features of the Pancreatic β-Cell Transcriptome
- Mol Endocrinol. | October 1, 2012
Let-7b/c Enhance the Stability of a Tissue-Specific mRNA during Mammalian Organogenesis as Part of a Feedback Loop Involving KSRP
- PLoS Genetics | July 26, 2012
Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing.
- NAR | July 18, 2012
Precursor MicroRNA-Programmed Silencing Complex Assembly Pathways in Mammals
- Mol Cell. | April 11, 2012
A Resource for the Conditional Ablation of microRNAs in the Mouse
- Cell Reports | March 29, 2012
Widespread RNA 3'-end oligouridylation in mammals
- RNA | January 30, 2012
An siRNA Screen in Pancreatic Beta Cells Reveals a Role for Gpr27 in Insulin Production
- PLoS Genet | January 12, 2012
Polymerase II Promoter Strength Determines Efficacy of microRNA Adapted shRNAs
- PLoS ONE | October 21, 2011
Posttranscriptional silencing of effector cytokine mRNA underlies the anergic phenotype of self-reactive T cells.
- Immunity | January 28, 2011
The microRNA-processing enzyme Dicer is dispensable for somite segmentation but essential for limb bud positioning.
- Dev. Biol. | January 20, 2011
Analysis of microRNA knockouts in mice
- Hum Mol Genet. | September 15, 2010
Dicer1 and miR-219 Are Required for Normal Oligodendrocyte Differentiation and Myelination
- Neuron | March 11, 2010
Expanded RNA-binding activities of mammalian Argonaute 2.
- Nucleic Acids Res. 37(22):7533-45. | December 1, 2009
Dicer ablation in oligodendrocytes provokes neuronal impairment in mice.
- Ann Neurol. 66(6):843-857 | November 30, 2009
Lentivirus production
- J Vis Exp. | October 2, 2009
Dicer is required for proper liver zonation
- J. Pathol | July 27, 2009
Chd1 regulates open chromatin and pluripotency of embryonic stem cells
- Nature | July 8, 2009
Rapid creation and quantitative monitoring of high coverage shRNA libraries.
- Nat Methods | May 17, 2009
LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages.
- FASEB J. | May 7, 2009
Up-regulation of miR-21 by HER2/neu Signaling Promotes Cell Invasion.
- J Biol Chem. | May 6, 2009
Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus
- J Neurosci. | April 23, 2009
Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice
- Developmental Biology | April 15, 2009
Genetic analyses reveal a requirement for Dicer1 in the mouse urogenital tract
- Mammalian Genome | March 1, 2009
Sertoli cell Dicer is essential for spermatogenesis in mice
- Dev Biol. | February 1, 2009
Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease
- J Am Soc Nephrol. | November 1, 2008
Mouse let-7 miRNA populations exhibit RNA editing that is constrained in the 5'-seed/ cleavage/anchor regions and stabilize predicted mmu-let-7a:mRNA duplexes
- Genome Res. | October 1, 2008
Dicer1 is required for differentiation of the mouse male germline
- Biol Reprod. | October 1, 2008
Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity.
- J Exp Med. | September 1, 2008
Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina
- J Neurosci. | May 7, 2008
Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration
- Proc Natl Acad Sci U S A. | April 8, 2008
Unintentional miRNA ablation is a risk factor in gene knockout studies: a short report
- PLoS Genet. | February 1, 2008
Members of the miRNA-200 family regulate olfactory neurogenesis
- Neuron. | January 10, 2008
Behind the scenes of a small RNA gene-silencing pathway
- Hum Gene Ther. | January 1, 2008
MicroRNA expression is required for pancreatic islet cell genesis in the mouse
- Diabetes. | December 1, 2007
Essential role for Dicer during skeletal muscle development
- Dev Biol. | November 15, 2007
Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells
- PLoS ONE. | April 25, 2007
Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2
- Cell. | April 20, 2007
Lentiviral Strategies for RNAi Knockdown of Neuronal Genes
- Current Protocols in Neuroscience | April 15, 2007
Duox2 exhibits potent heme peroxidase activity in human respiratory tract epithelium
- FEBS Lett. | October 2, 2006
RNA interference in embryonic stem cells and the prospects for future therapies
- Gene Ther. | March 1, 2006
Dicer function is essential for lung epithelium morphogenesis
- Proc Natl Acad Sci U S A. | February 14, 2006
The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development
- Nature. | December 1, 2005
MicroRNAs and endocrine biology
- J Endocrinol. | December 1, 2005
Slowing down the Ras lane: miRNAs as tumor suppressors?
- Sci STKE. | August 16, 2005
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation
- Science. | August 12, 2005
The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb
- Proc Natl Acad Sci U S A. | August 2, 2005
Small RNAs and immunity
- Immunity. | December 1, 2004
MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression
- Nat Genet. | October 1, 2004
Cre-lox-regulated conditional RNA interference from transgenes
- Proc Natl Acad Sci U S A. | July 13, 2004
MicroRNAs and cancer
- Semin Cancer Biol. | August 1, 2003
RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription
- Proc Natl Acad Sci U S A. | March 4, 2003
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
- Nat Genet. | March 1, 2003
Small interfering RNA-mediated gene silencing in T lymphocytes
- J Immunol. | November 15, 2002
Gene silencing in mammals by small interfering RNAs
- Nat Rev Genet. | October 1, 2002
CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells
- Dev Cell. | September 1, 2002
Gene silencing using micro-RNA designed hairpins
- RNA | June 1, 2002
Identification of candidate mitochondrial RNA editing ligases from Trypanosoma brucei
- RNA. | February 1, 2001
Processing of polycistronic guide RNAs is associated with RNA editing complexes in Trypanosoma brucei
- EMBO J. | October 16, 2000
Trypanosoma brucei guide RNA poly(U) tail formation is stabilized by cognate mRNA
- Mol Cell Biol. | February 1, 2000
Insertional and deletional RNA editing in trypanosome mitochondria
- Nucleic Acids Symp Ser. | January 1, 1997
