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MicroRNAs and endocrine biology.
Publication Type:Journal Article
Source:J Endocrinol, Volume 187, Issue 3, p.327-32 (2005)
Keywords:Adipocytes, Argonaute Proteins, Cell Differentiation, Diabetes Mellitus, Type 2, Endocrine Glands, Eukaryotic Initiation Factor-2, Gene Expression Regulation, Humans, MicroRNAs, Models, Biological, Pancreas, Peptide Initiation Factors, Transcription, Genetic
<p>microRNAs (miRNAs) are highly conserved, non-coding RNAs that powerfully regulate gene expression at the post-transcriptional level. These fascinating molecules play essential roles in many biological processes in mammals, including insulin secretion, B-cell development, and adipocyte differentiation. This review provides a general background regarding current knowledge about miRNA biogenesis and the potential contributions of these RNAs to endocrine function.</p>