Development: sketch for a theory of Oct4.


Publication Type:

Source:

Curr Biol, Volume 23, Issue 22, p.R1014-6 (2013)

Keywords:

Animals, Cell Adhesion, Embryonic Stem Cells, Gene Regulatory Networks, Octamer Transcription Factor-3, Xenopus Proteins

Abstract:

<p>How is it that Oct4, a transcription factor that controls pluripotency in stem cells, also controls lineage specification? A recent study investigating common Oct4 targets in vertebrate species indicates an evolutionarily conserved role in mediating cell adhesion. This finding may help decipher Oct4's versatility in governing stem cell behaviors.</p>