postdoctoral and staff positions are available


Postdoc positions are available in the McManus lab to study biological processes relating to noncoding RNA pathways.  If you are interested in conducting high-throughput genomic screens, or using the mouse as a model to understand noncoding RNA biology, this lab could be for you. We have a broad focus to understand the biology of gene expression as related to RNA.  ImageThere are projects related to long noncoding RNAs and biology regulated to post-transcriptional gene regulation and epigenetics.  There are available projects that involve the study of small noncoding RNAs of biological significance, and genetic factors involved in noncoding RNA genesis and regulation of gene expression.  Projects are available that center on mammalian systems that use powerful CRISPR, peptide, siRNA, and shRNA libraries, unique Cas9 systems, mouse transgenics, and novel approaches aimed at dissecting mechanisms of RNA biology.  The McManus Lab is an excellent training environment and UCSF offers astounding opportunities to develop your career.  Anyone interested in molecular mechanisms of gene expression as related to noncoding RNAs can apply.

Please send a pdf copy of your CV by email to Lily Yu, cc to Michael T. McManus.  Include "postdoc position" in the subject line. Send a list of three references to:
Lily Yu (administrative assistant)
lily.yu@ucsf.edu 

UCSF Specialist Scientist Position: High Throughput CRISPR/Cas9 screening

The McManus Lab at University of California San Francisco is seeking a lab specialist. Our laboratory is broadly interested in RNA and the regulation of gene expression. One focus of our research is to determine the mechanisms for gene regulation and function as related to development and human disease. The candidate will be working in a small team who are engaged in basic research and help conduct high-throughput genome-wide CRISPR/Cas9 screens, including virus production and transduction of cultured cells, and perform deep sequence analysis.  

Candidate must be willing to work as an integral member of a research team, be organized, and have strong communication skills. This is a full-time position at UCSF and ideal position for applicants interested in basic science.

Qualifications: 
Minimum of a BA/BS in biological/biochemical science or related field 
Experience with mammalian tissue culture
Knowledge of and experience with basic molecular biology protocols
Ability to work under minimal supervision 
Experience with next-generation sequencing and quantitative data analysis
Experience with flow cytometry (FACs)
Strong organization, and oral/written communication skills 

Responsibilities: 
Execute high-throughput genome-wide screens
Perform cell culture
Assist in a variety of molecular reagent preparations including next-generation sequencing Perform DNA purification, PCR, cloning, and related molecular biology techniques
Record keeping and data entry
Work with a small team and communicate data clearly
Perform other duties as assigned

Please send a C.V. and three references to Lily Yu, e-mail: lily.yu@ucsf.edu, cc to Michael T. McManus.

Electronic submissions in PDF format is required, and include the words "UCSF Specialist Position: High Throughput CRISPR/Cas9 screening" in the subject line. DO NOT contact the McManus lab directly.

UCSF ViraCore Specialist Scientist Position

The UCSF ViraCore and the McManus Lab at University of California San Francisco is seeking a Specialist. A major focus of the position will be to assist in the development and the derivation of large-scale genomic resources. The candidate will engage wetbench research in a team setting and help oversee a University Core facility. Candidate must be willing to work as an integral member of a research team, be organized, and have strong communication skills. This is a full-time position at UCSF and ideal position for applicants having a sincere fascination with basic science and the interface between industry and academia.

MS or PhD in biological sciences or a related science- alternatively a BA/BS in biological sciences or a related science with at least two or more years of recent, directly related work experience following degree completion.

Qualifications: Knowledge of and experience with basic cell and molecular biology protocols: tissue culture, flow cytometry, PCR, DNA sequence analysis and cloning; comfort working with instrumentation and computers; maintenance of accurate notebooks and computer files; team player with good communication and interpersonal skills; willingness to learn, seek out advice and admit errors; highly motivated to succeed. Analytical skills and comfort with basic statistics a plus. Strong organization skills and the ability to multitask and work under minimal supervision is key for this position. 

Responsibilities: 
Perform molecular biology techniques including DNA extraction, PCR, plasmid preparation and basic cloning. 
Tissue culture and flow cytometry
Perform basic molecular and cellular biology experiments
Maintenance of accurate notebooks and computer records
Oversee virus production 
Managerial duties related to customer service and possibly personnel oversight
Perform other duties as assigned

Please send a C.V. and three references to Lily Yu, e-mail: lily.yu@ucsf.edu, cc to Michael T. McManus. 

Electronic submissions in PDF format is required, and include the words "ViraCore Lab Specialist" in the email subject line. DO NOT contact the ViraCore or the McManus lab directly.